ADHD and the Dopamine Transporter Gene

• Family-based controlled association study of the dopamine transporter in ADHD: Cook, E.H., Stein, M.A., Krasowski, M.D., Cox, N.J., Olkon, D.M., Kieffer, J.E., Leventhal, B.L.: Association of attention deficit disorder and the dopamine transporter gene. American Journal of Human Genetics 1995,56:993-998
• Other family-based controlled studies of the dopamine transporter gene and ADHD
  • Gill et al. Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Molecular Psychiatry 1997,2:311-313 (extension: Daly et al. Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Molecular Psychiatry 1999,4:192-196)
  • Waldman et al. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: Heterogeneity owing to diagnostic subtype and severity. American Journal of Human Genetics 1998,63:1767-1776
  • Palmer et al. No evidence of linkage or linkage disequilibrium between DAT1 and attention deficit hyperactivity disorder in a large sample. Psychiatric Genetics 1999,9: 157-160
  • Holmes et al. A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficit hyperactivity disorder. Molecular Psychiatry 2000,5:523-530
  • Swanson, J. M. et al. Dopamine genes and ADHD. Neurosci Biobehav Rev 2000,24: 21-25
  • Barr et al. Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit hyperactivity disorder. Biological Psychiatry 2001,49:333-339
  • Curran et al. Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples. Mol Psychiatry 2001,6:425-428
  • Todd et al. No association of the dopamine transporter gene 3' VNTR polymorphism with ADHD subtypes in a population sample of twins. American Journal of Medical Genetics (Neuropsychiatric Genetics) 2001,105:745-748.
• Mutation screening of dopamine transporter in ADHD: Vandenbergh et al. Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations. Molecular Psychiatry 2000,5:283-292

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