Serotonin transporter gene and autism

Evidence of linkage between the serotonin transporter and autistic disorder. Molecular Psychiatry 1997,2:247-250

Kim S et al. Transmission disequilibrium mapping in the serotonin transporter gene (SLC6A4) region in autistic disorder. Molecular Psychiatry 2002,7:278-288

• Other family-based controlled studies of the serotonin transporter gene in autism and/or studies looking at relationship of serotonin transporter gene and hyperserotonemia of autism:
  • Klauck et al. Serotonin transporter (5-HTT) gene variants associated with autism? Human Molecular Genetics 1997,6:2233-2238
  • Maestrini...International Molecular Genetic Study of Autism Consortium. Serotonin transporter (5-HTT) and gamma-aminobutyric acid receptor subunit 3 (GABRB3) gene polymorphisms are not associated with autism in the IMGSA families. Am J Med Genet (Neuropsychiatric Genetics) 1999,88:492-496
  • Persico et al. Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples. Am J Med Genet (Neuropsychiatric Genetics) 2000,96:123-127
    • Persico et al. Serotonin transporter gene promoter variants do not explain the hyperserotoninemia in autistic children. Mol Psychiatry 2002;7:795-800
  • Yirmiya et al. Evidence for an association with the serotonin transporter promoter region polymorphism and autism. Am J Med Genet (Neuropsychiatric Genetics) 2001,105:381-386
  • Tordjman et al. Role of the serotonin transporter gene in the behavioral expression of autism. Mol Psychiatry 2001,6:434-439
    • Anderson et al. Serotonin transporter promoter variants in autism: functional effects and relationship to platelet hyperserotonemia. Molecular Psychiatry 2002,7:831-836
  • Betancur C et al. Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder. Molecular Psychiatry 2002,7:67-71
  • McCauley et al. Linkage and association analysis at the serotonin transporter (SLC6A4) locus in a rigid-compulsive subset of autism. Am J Med Genet (Neuropsychiatric Genet) 2004,127:104-112
  • New Sutcliffe et al.: Allelic heterogeneity at the serotonin transporter locus (SLC6A4) confers susceptibility to autism and rigid-compulsive behaviors. Am J Hum Genet 2005,77:265-279
  • New (8/18/05) Devlin et al: Autism and the serotonin transporter: the long and short of it. Molecular Psychiatry published online in advance of print
• Study of function of rare amino acid variants in serotonin transporter gene
  • New Prasad et al.: Human serotonin transporter variants display altered sensitivity to protein kinase G and p38 mitogen-activated protein kinase. Proc Natl Acad Sci 2005 Jul 29; [Epub ahead of print] 

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